I have a Saitek keyboard, AMD Phenom 9500 Quadcore, 4 gig memory, 960 gt Nvidia graphics card, with 500gig hard drive. I do not have a keyboard layout. I just follow whatever is when I press F1 for help with key commands.
FSO - and by extension Wing Commander Saga can get a little fonky when dealing with non-QWERTY layout, meaning it often considers your keyboard to be QWERTY while it isn't. For instance, if you've got an AZERTY keyboard, you have to press alt-Q instead of alt-A to activate the autopilot.